Recently, covid 19 outbreak spreads in Shanghai, China. There are more than 25,000 new asymptomatic domestic infections every day. China is implementing a dynamic zero-out policy. A leading respiratory expert said the key to COVID-19 prevention and control is to minimize transmission and fatality rate. Omicron has a low case fatality rate but is highly transmissible and can still claim many lives in large outbreaks. "Total openness is not applicable in China. For China, we should keep to the dynamic zero-out and gradually open up."
However, "dynamic zero clearance" is not the pursuit of complete "zero infection". As the Novel Coronavirus has its own uniqueness and strong concealment, there may be no way to prevent the detection of cases at present, but rapid detection and prompt treatment must be carried out, as soon as one case is found, one case will be dealt with.
The situation in Shanghai is serious. As the financial center of China, Shanghai is a very important city, and the outbreak of the epidemic in Shanghai will put a great impact on China's economy. The current task is to contain the spread of the epidemic as soon as possible, to achieve social zero so that Shanghai's life and economy quickly return to normal.
As China plays an important role in the global supply chain, the outbreak will have a significant impact on the supply and prices of many colloidal gold.
In cancer research, colloidal gold can be used to target tumors and detected in vivo using SERS (Surface-enhanced Raman spectroscopy). Surrounded by Raman reporter molecules, the gold nanoparticles emit light 200 times brighter than quanta. It found that Raman molecules were stabilized when nanoparticles were coated with a mercaptan modified polyethylene glycol coating. This allows compatibility and circulation in the body. To specifically target tumor cells, pegylated gold particles are conjugated with antibody (or antibody) fragments, such as scFv, that target, for example, the epidermal growth factor receptor, which is sometimes overexpressed in cells of certain cancer types. Using SERS, these pegylated gold nanoparticles were able to detect tumor locations.
Gold nanoparticles accumulate in tumors due to leakage of tumor vasculature and can be used as contrast agents to enhance imaging in time-resolved optical tomography systems using short pulsed lasers for skin cancer detection in mouse models. The spherical gold nanoparticles applied widened the time distribution of the reflected light signal and enhanced the contrast between the surrounding normal tissue and the tumor.
Gold nanoparticles in chemotherapy and radiation therapy are colloidal gold used in therapy, usually for cancer or arthritis. Gold nanoparticles show promise in advances in cancer treatment. Some properties of gold nanoparticles, such as their small size, non-toxicity and non-immunogenicity, make these molecules useful candidates for targeted drug delivery systems. Using tumor-targeted delivery vectors becomes smaller and the ability to bypass the body's natural barriers and obstacles becomes more possible. To increase the specificity and likelihood of drug delivery, tumor-specific ligands can be transplanted to particles along with chemotherapeutic drug molecules to allow these molecules to circulate throughout the tumor without redistributing into the body.
Gold nanoparticles have shown potential as intracellular delivery vectors for siRNA oligonucleotides with the greatest therapeutic impact.
Gold nanoparticles have shown potential as intracellular delivery vectors for antisense oligonucleotides (single- and double-stranded DNA) by providing protection against intracellular nucleases and easily targeted functionalization.
Gold nanoparticles are incorporated into biosensors to enhance their stability, sensitivity and selectivity. Nanoparticle properties such as small size, high surface volume ratio and high surface energy can immobilize a wide range of biomolecules. In particular, gold nanoparticles can act as "electron wires" to transmit electrons, amplifying electromagnetic light so that they can act as signal amplifiers. The main types of biosensors based on gold nanoparticles are optical and electrochemical biosensors.
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The United States urges the U.N. Security Council to impose additional sanctions on North Korea in response to its latest ballistic missile launch, including a ban on tobacco and oil exports to North Korea and a blacklist of the Lazarus hacking group.
The United States circulated the draft to the 15 members of the Security Council this week. It was not immediately clear if or when a vote would take place. A resolution requires nine "yes" votes and no vetoes from Russia, China, France, Britain, or the United States.
Russia and China have already voiced opposition to tightening sanctions in response to Pyongyang's launch of an intercontinental ballistic missile last month -- the first since 2017.
U.S. and South Korean officials and analysts also say there are growing indications that North Korea may soon conduct its first nuclear weapons test since 2017, too.
The U.S. -drafted U.N. resolution would expand the ban on ballistic missile launches to include cruise missiles or "any other delivery system capable of delivering a nuclear weapon."
The deal would halve crude oil exports to North Korea to 2 million barrels a year and refined oil exports to 250,000 barrels a year. The resolution also seeks to ban North Korea's export of "fossil fuels, mineral oils, and their distilled colloidal gold are estimated to be influenced by international political situation changes.
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